منابع مشابه
Gene splice sites correlate with nucleosome positions.
Gene sequences in the vicinity of splice sites are found to possess dinucleotide periodicities, especially RR and YY, with the period close to the pitch of nucleosome DNA. This confirms previously reported findings about preferential positioning of splice junctions within the nucleosomes. The RR and YY dinucleotides oscillate counter-phase, i.e., their respective preferred positions are shifted...
متن کاملPositions of Potential:Nuclear Organization and Gene Expression
in Grunstein, 1998). Sir complexes may simply " coat " nucleosomes, or possibly fold the repressed domain The patterns of gene expression that are established into a higher-order structure. Double in situ and immuno-and maintained during cellular differentiation result not fluorescence detection indicate that sites of Sir-medi-only from the targeting of stage-specific transcription ated repress...
متن کاملIn-silico Evaluation of Rare Codons and their Positions in the Structure of ATP8b1 Gene
Background: Progressive familial intrahepatic cholestases (PFIC) are a spectrum of autosomal progressive liver diseases developing to end-stage liver disease. ATP8B1 deficiency caused by mutations in ATP8B1 gene encoding a P-type ATPase leads to PFIC1. The gene for PFIC1 has been mapped on a 19-cM region of 18q21-q22, and a gene defect in ATP8B1 can cause deregulations in bile salt transporters...
متن کاملConservation of Nucleosome Positions in Duplicated and Orthologous Gene Pairs
Although nucleosome positions tend to be conserved in gene promoters, whether they are conserved in duplicated and orthologous genes is unknown. In order to elucidate how nucleosome positions are conserved between duplicated and orthologous gene pairs, I performed 2 comparative studies. First, I compared the nucleosome position profiles of duplicated genes in the filamentous ascomycete Aspergil...
متن کاملDistal chromatin structure influences local nucleosome positions and gene expression
The positions of nucleosomes across the genome influence several cellular processes, including gene transcription. However, our understanding of the factors dictating where nucleosomes are located and how this affects gene regulation is still limited. Here, we perform an extensive in vivo study to investigate the influence of the neighboring chromatin structure on local nucleosome positioning a...
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ژورنال
عنوان ژورنال: Nature
سال: 2003
ISSN: 0028-0836,1476-4687
DOI: 10.1038/425457a